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Absorption of anesthetic into systemic circulation by injection into extremely vascular area. Clinical course tends to be a dose-dependant progression from cns symptoms to cvs symptoms and death … Adding vasoconstrictor to local anesthetics can result in reduced systemic toxicity and increased duration of anesthetic because the vasoconstrictor reduces the rate of absorption.
Any and every injection into a presumed epidural catheter may unexpectedly be administered intravascularly or intrathecally. Local anesthetic should always be administered incrementally with … Simultaneous administration of different local anesthetic formulations further reduces the minimum toxic dose of each formulation of local anesthetic. Utilize clinically appropriate agents, not exceeding …
