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Following abraxane administration to patients with solid tumors, paclitaxel is evenly distributed into blood cells and plasma and is highly bound to plasma proteins (94%). Abraxane label includes a black box warning restricting use in patients with baseline neutrophil counts of less than 1,500 cells/mm3, and frequent peripheral blood cell counts should be performed to monitor … Do not administer abraxane to patients with total bilirubin > 5 x uln or ast > 10 x uln [see dosage and administration (2. 4), warnings and precautions (5. 6) and clinical pharmacology (12. 3)].
Non-small cell lung cancer: The recommended dose of abraxane is 100 mg/m2 administered as an intravenous infusion over 30 minutes on days 1, 8 and 15 of each 21-day cycle. The recommended … Following intravenous administration of abraxane, paclitaxel plasma concentrations declined in a biphasic manner, the initial rapid decline representing distribution to the peripheral
