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Neurotherapeutics 2023 peripheral administration of the kv1. 3-blocking peptide hstx1 [r14a] improves cognitive performance in senescence accelerated samp8 mice It is shown that microglial expression of kv1. 3 is increased in senescence accelerated mice (samp8), an animal model of sporadic ad, and that subcutaneous dosing of hstx1 [r14a] (1 mg/kg) every other Γ’β¬Β¦ Abstract the peptide hstx1 [r14a] is a potent and selective blocker of the voltage-gated potassium channel kv1. 3, which is a highly promising target for the treatment of autoimmune diseases and Γ’β¬Β¦
To overcome the poor oral absorption and consequent need for regular injections, the potential of the buccal mucosa for systemic delivery of hstx1 [r14a] was investigated. Studies have shown that reducing neuroinflammation through the non-selective blockade of microglial kv1. 3 has the potential to improve cognitive function in mouse models of familial ad. Hstx1 [r14a] is a selective and potent peptide inhibitor of the kv1. 3 channel (ic 50 Γ’ΛΒΌ 45 pm) that has been shown to decrease cytokine levels in a lipopolysaccharide (lps)-induced mouse model of Γ’β¬Β¦
